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KMID : 0606920060140040202
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.202 ~ p.206
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Phellopterin Suppresses Airway Mucin Secretion induced by Adenosine Triphosphate
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Heo Ho-Jin
Kim Cheol-su
Lee Hyun-Jae
Kim Jin-Woong
Kim Yeong-Shik
Kang Sam-Sik
Seo Un-Kyo
Kim Yun-Hee
Seok Jeong-Ho
Lee Choong-Jae
Park Yang-Chun
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Abstract
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Angelicae Dahiricae Radix has been used for controlling inflammatory respiratory discases in oriental medicine and their components, phellopterin, isoimperatorin and byakangelicol were reporled to have various bio-logical effects. In this study, we investigated whether phellopterin, isoimperatorin and byakangelicol affect ade- nosine triphosphate (ATP)-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3-mucin secretion. The results were as follows : 1) phellopterin significantly inhibited ATP-induced mucin secretion : 2) However, isoimperatorin and byakangelicol did not affect ATP-induced mucin secretion, significantly. This result suggests that phellopterin can regulatc ’mucin secretion induced by ATP’ - a phenomenon simulating mucus over- production from inflamed airway epithelial cells - by directly acting on airway mucin-secreting cells. Therefore, phellopterin should further be investigated for the possible use as mucoregulators in the treatment of inflamma- tory airway discases.
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KEYWORD
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Airway, Mucin, Phellopterin, Isoimperatorin, Byakangelicol
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